Acetic Acid → HCID 178472516, 화합물

HRID 2242253노트

반응식

HRID 2242253 반응식
Cl.[CH2:2]([O:4][C:5]([C@H:7]1[CH2:10][C@@H:9]([NH2:11])[CH2:8]1)=[O:6])[CH3:3].[CH2:12]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:26]=[C:25]([C:27]3[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=3)[O:24][N:23]=2)=[CH:18][CH:17]=1)[CH:13]([CH3:15])[CH3:14].C(O)(=O)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C1COCC1>[CH2:12]([C:16]1[CH:17]=[CH:18][C:19]([C:22]2[N:26]=[C:25]([C:27]3[CH:28]=[CH:29][C:30]([CH2:31][NH:11][C@@H:9]4[CH2:10][C@H:7]([C:5]([O:4][CH2:2][CH3:3])=[O:6])[CH2:8]4)=[CH:33][CH:34]=3)[O:24][N:23]=2)=[CH:20][CH:21]=1)[CH:13]([CH3:15])[CH3:14]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 5049666Sodium triacetoxyborohydrideHCID 592043124-[3-(4-Isobutylphenyl)-1,2,4-oxadiazol-5-yl]benzaldehydeHCID 178472514HCID 178472514, 화합물

생성물 1

HCID 178472516HCID 178472516, 화합물수율 55.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

cis-3-Amino-cyclobutanecarboxylic acid ethyl ester hydrochloride (0.193 g, 1.35 mmol) was added to a solution of 4-[3-(4-isobutylphenyl)-1,2,4-oxadiazol-5-yl]benzaldehyde (0.333 g, 1.08 mmol), acetic acid (2 mL) and THF (18 mL) and stirred for 30 minutes. Sodium triacetoxyborohydride (0.500 g, 2.36 mmol) was added to the reaction mixture, stirred at room temperature for 16 hours, and concentrated in vacuo to give a white solid. The solid was triturated with water, filtered and dried to give the title compound (0.260 g, 55% yield) as a white solid.

후처리

  1. stirringstirred at room temperature for 16 hours
  2. concentrationconcentrated in vacuo
  3. customto give a white solid
  4. customThe solid was triturated with water
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-21e9c495d4164c65a9ae08cfbea54bd5
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671043B2

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