Triethylamine → HCID 178472517, 화합물

HRID 2242257노트

반응식

HRID 2242257 반응식
Cl.[CH2:2]([O:4][C:5]([C@H:7]1[CH2:10][C@@H:9]([NH2:11])[CH2:8]1)=[O:6])[CH3:3].C(N(CC)CC)C.[CH2:19]([C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:33][C:32]([C:34]3[CH:41]=[CH:40][C:37]([CH:38]=O)=[CH:36][CH:35]=3)=[N:31][N:30]=2)=[CH:25][CH:24]=1)[CH:20]([CH3:22])[CH3:21].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[CH2:19]([C:23]1[CH:24]=[CH:25][C:26]([C:29]2[O:33][C:32]([C:34]3[CH:35]=[CH:36][C:37]([CH2:38][NH:11][C@@H:9]4[CH2:10][C@H:7]([C:5]([O:4][CH2:2][CH3:3])=[O:6])[CH2:8]4)=[CH:40][CH:41]=3)=[N:31][N:30]=2)=[CH:27][CH:28]=1)[CH:20]([CH3:22])[CH3:21]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 5049666Sodium triacetoxyborohydride2회HCID 592042884-[5-(4-Isobutylphenyl)-1,3,4-oxadiazol-2-yl]benzaldehydeHCID 178472514HCID 178472514, 화합물2회

생성물 1

HCID 178472517HCID 178472517, 화합물수율 88%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of cis-3-amino-cyclobutanecarboxylic acid ethyl ester hydrochloride (0.181 g, 1.01 mmol), triethylamine (0.10 mL, 0.72 mmol) and dichloromethane (8 mL) was stirred at room temperature for 30 minutes. 4-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]benzaldehyde (0.181 mg, 1.04 mmol) was added to the reaction mixture and stirred for 2 hours. Sodium triacetoxyborohydride (0.213 g, 1.01 mmol) was added to the reaction mixture and stirred for 16 hours. Additional cis-3-amino-cyclobutanecarboxylic acid ethyl ester hydrochloride (0.100 mg, 0.773 mmol) and sodium triacetoxyborohydride (0.213 g, 1.01 mmol) was added to the reaction mixture and stirred for 72 hours. The reaction mixture was concentrated in vacuo and the resulting residue was triturated with water, filtered and dried to provide the title compound (0.303 g, 88% yield) as a white solid.

후처리

  1. stirringstirred for 2 hours
  2. stirringstirred for 16 hours
  3. stirringstirred for 72 hours
  4. concentrationThe reaction mixture was concentrated in vacuo
  5. customthe resulting residue was triturated with water
  6. filtrationfiltered
  7. customdried

출처 및 근거

ORD 기록
ord-f91ff40ccba045b4aa7509e4f2fa1e47
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671043B2

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