Thionyl Chloride → HCID 19744543, 화합물

HRID 2242361노트

반응식

HRID 2242361 반응식
S(Cl)([Cl:3])=O.[N:5]1([C:10]2[CH:11]=[C:12]([CH2:16]O)[CH:13]=[CH:14][CH:15]=2)[CH:9]=[CH:8][N:7]=[CH:6]1>CN(C=O)C>[Cl:3][CH2:16][C:12]1[CH:11]=[C:10]([N:5]2[CH:9]=[CH:8][N:7]=[CH:6]2)[CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 197444983-(1H-Imidazol-1-yl)benzenemethanol

생성물 1

HCID 19744543HCID 19744543, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Thionyl chloride (4.0 ml, 54.0 mmol) was added to a solution of (3-imidazol-1-yl-phenyl)-methanol (3.17 g, 17.0 mmol) in DMF (50 ml) and the reaction stirred at room temperature for 40 h. The solvent was evaporated, the residue diluted with DCM and washed with water, neutralised with aqueous sodium bicarbonate (pH 9-10) and then extracted with DCM (3×). The organic phase was dried over sodium sulfate, filtered and concentrated to give 1-(3-chloromethyl-phenyl)-1H-imidazole as an orange oil (5.3 g, crude contaminated with DMF).

후처리

  1. customThe solvent was evaporated
  2. additionthe residue diluted with DCM
  3. washwashed with water
  4. extractionextracted with DCM (3×)
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a6cc3b32698a402ab41ee8462d5c99e9
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671080B2

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