Ethanol → Ethyl 3-amino-2-methylpropanoate hydrochloride

HRID 2242386노트

반응식

HRID 2242386 반응식
[NH2:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].S(Cl)([Cl:10])=O.[CH2:12](O)[CH3:13]>C(Cl)Cl>[ClH:10].[CH2:12]([O:5][C:4](=[O:6])[CH:3]([CH3:7])[CH2:2][NH2:1])[CH3:13]

참가 물질

5

반응물 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 64956Beta-Aminoisobutyric Acid

생성물 1

HCID 19611788Ethyl 3-amino-2-methylpropanoate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

실험 절차

3-Aminoisobutyric acid (1.00 g, 9.7 mmol) was stirred in DCM under nitrogen and thionyl chloride (1.4 ml, 19.4 mmol) was added at room temperature. The reaction was heated to 50° C. for 2 h. The solvent and any excess thionyl chloride were removed under reduced pressure and the oil obtained was dissolved in ethanol (20 ml) stirring at room temperature for 18 h. The solvent was removed under reduced pressure to give 3-aminoisobutyric acid ethyl ester hydrochloride as a viscous, cloudy oil (1.47 g, 90%).

후처리

  1. customThe solvent and any excess thionyl chloride were removed under reduced pressure
  2. customthe oil obtained
  3. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-6b0fbca56b8d462aa450a7993f682fa6
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07671080B2

반응 노트

불러오는 중…