Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → Trandolapril
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 반응물 | (2S,3aR,7aS)-octahydro-1H-indole-2-carboxylic acid | HCID 7018901 | — |
| 반응물 | N-(1-ethoxycarbonyl-3-phenylpropyl)-L-alanine | HCID 13044262 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Trandolapril | HCID 5484727 | 92% |
반응 단계
To 2.79 g of (S)-1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanine and 1.75 g of (2S,3aR,7aS)-octahydro-1H-indol-2-carboxylic acid in 100 ml of acetonitrile and 5 ml DMF first 2.9 ml of triethylamine and then with stirring 3.8 g O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate were and the stirring of the mixture was continued for 30 minutes at room temperature. Finally, 300 ml of saturated NaCl solution was added and the mixture was extracted twice with 100 ml of ethyl acetate. After isolation of the product, which was done by the same way as in example 1, 3.96 g (92%) of trandolapril was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07671215B2 |
| 출처 데이터셋 | uspto-grants-2010_03 |
| ORD ID | ord-ea87d675a8b64bf4ac30b3d92c8d90c9 |
| 출처 메모 | uspto-grants-2010_03 |