Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178512066, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Furonitrile | HCID 69245 | — |
| 반응물 | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | HCID 178512066 | HCID 178512066 | 72% |
반응 단계
A solution of 3,5-dibromo-pyrazin-2-ylamine (608 mg, 2.4 mmol), furan-2-carbonitrile (297 uL, 3.39 mmol) and AlCl3 (320 mg, 2.4 mmol) in dichloroethane (6 ml) was heated at 115° C. overnight. The reaction was cooled to room temperature and water (5 ml) was added. After 30 minutes, the resulting precipitate was collected and purified by column chromatography (SiO2, THF) to afford 595 mg (72%) of N-(3,5-dibromo-pyrazin-2-yl)-furan-2-carboxamidine as a yellow solid. 1H NMR (300 MHz, DMSO-d6) δ 6.73 (dd, J=3.4, 1.8 Hz, 1H), 7.3 (dd, J=3.1 Hz, 1H), 7.98 (s, 1H), 8.49(s, 1H), 8.69 (br. s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07674791B2 |
| 출처 데이터셋 | uspto-grants-2010_03 |
| ORD ID | ord-e652283c74b74d7c9aa07581e79364ed |
| 출처 메모 | uspto-grants-2010_03 |