Trifluoroacetic acid → 2-Furan-2-yl-6-piperazin-1-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

HRID 2242908노트

반응식

HRID 2242908 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[C:16]([NH:28]C(OC(C)(C)C)=O)[C:17]3[N:18]([N:20]=[C:21]([C:23]4[O:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)[CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[O:24]1[CH:25]=[CH:26][CH:27]=[C:23]1[C:21]1[N:22]=[C:17]2[C:16]([NH2:28])=[N:15][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:19][N:18]2[N:20]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 685441504-(8-Tert-butoxycarbonylamino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 111619332-Furan-2-yl-6-piperazin-1-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-(8-tert-butoxycarbonylamino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester (140 mg, 0.29 mmol; see Example 16 (i) above) in methylene chloride (4 mL) was added trifluoroacetic acid (400 μL). The reaction was stirred at room temperature for 2 hours. After the solvent and extra trifluoroacetic acid was evaporated, the residue was dissolved in methylene chloride (4 mL). The title compound in methylene chloride was divided into two portions and used for further reactions (see Example 17 and Example 18 below) without further purification.

후처리

  1. customAfter the solvent and extra trifluoroacetic acid was evaporated
  2. dissolutionthe residue was dissolved in methylene chloride (4 mL)
  3. customused for further reactions (see Example 17 and Example 18 below) without further purification

출처 및 근거

ORD 기록
ord-c8aa57986f73411abc9241d510029279
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674791B2

반응 노트

불러오는 중…