Potassium Carbonate → Ethyl 6-iodo-1-(2-morpholinoethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

HRID 2243053노트

반응식

HRID 2243053 반응식
F[C:2]1[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:3]=1[C:4]([C:6](=[CH:12][NH:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[I:26][C:23]1[CH:22]=[C:3]2[C:2](=[CH:25][CH:24]=1)[N:13]([CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)[CH:12]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:4]2=[O:5]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 178472024HCID 178472024, 화합물2회

생성물 1

HCID 59208337Ethyl 6-iodo-1-(2-morpholinoethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of ethyl 2-(2-fluoro-5-iodobenzoyl)-3-(2-morpholinoethylamino)acrylate (Intermediate 23, 358 mg, 0.75 mmol) and potassium carbonate (208 mg, 1.50 mmol) in DMF (7 mL) was heated to 100° C. for 4 h. The reaction mixture was cooled to room temperature, filtered, and concentrated under reduced pressure. The solid that formed was placed under high vacuum overnight (328 mg) to yield the desired product. MS (ESP): 457 (M+H+) for C18H21IN2O4; NMR: 1.28 (t, J=7 Hz, 3H), 2.43 (m, 4H), 2.61 (m, 2H), 3.50 (m, 4H), 4.22 (q, J=7 Hz, 2H), 4.46 (m, 2H), 7.67 (d, J=9 Hz, 1H), 8.05 (m, 1H), 8.50 (s, 1H), 8.63 (s, 1H).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure
  3. customThe solid that formed
  4. customwas placed under high vacuum overnight (328 mg)

출처 및 근거

ORD 기록
ord-91e0d13955024ae5b3eab593d6b80b20
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674801B2

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