Phenacyl bromide → 1-(5-Bromo-4-(4-phenylthiazol-2-yl)pyridin-2-yl)-3-ethylurea

HRID 2243076노트

반응식

HRID 2243076 반응식
[Br:1][C:2]1[C:3]([C:14](=[S:16])[NH2:15])=[CH:4][C:5]([NH:8][C:9]([NH:11][CH2:12][CH3:13])=[O:10])=[N:6][CH:7]=1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=O>C(#N)C>[Br:1][C:2]1[C:3]([C:14]2[S:16][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:15]=2)=[CH:4][C:5]([NH:8][C:9]([NH:11][CH2:12][CH3:13])=[O:10])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6259Phenacyl bromideHCID 59208439AZD7118 Bromo Thioamide2회

생성물 1

HCID 592085041-(5-Bromo-4-(4-phenylthiazol-2-yl)pyridin-2-yl)-3-ethylurea수율 84.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of 5-bromo-2-(3-ethylureido)pyridine-4-carbothioamide (Intermediate 42, 0.146 g, 0.48 mmol) in acetonitrile (3 mL), 2-bromo-1-phenylethanone (0.105 g, 0.53 mmol) was added and the reaction mixture was heated to 80° for 16 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting solids were filtered and washed with acetonitrile to yield 164 mg of the title compound as an off-white solid.

후처리

  1. additionwas added
  2. temperaturethe reaction mixture was heated to 80° for 16 h
  3. concentrationconcentrated under reduced pressure
  4. filtrationThe resulting solids were filtered
  5. washwashed with acetonitrile

출처 및 근거

ORD 기록
ord-5f795704f2194ca29e815cfebf151739
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674801B2

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