HCID 86600007, 화합물 → HCID 68593891, 화합물

HRID 2243145노트

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HRID 2243145 반응식
[N:1]([CH:4]([C:10]1[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:12]=[CH:13][N:14]=1)[CH:5]([CH2:8][CH3:9])[CH2:6][CH3:7])=[N+]=[N-]>CO.[Pd]>[CH2:15]([N:11]1[CH:12]=[CH:13][N:14]=[C:10]1[CH:4]([NH2:1])[CH:5]([CH2:8][CH3:9])[CH2:6][CH3:7])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

4

반응물 1

HCID 86600007HCID 86600007, 화합물

생성물 1

HCID 68593891HCID 68593891, 화합물수율 84%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 5% Pd/C (200 mg) and 2-(1-azido-2-ethylbutyl)-1-benzyl-1H-imidazole (585 mg, 2.06 mmol) in methanol (25 mL) was shaken on a Parr apparatus for 1 h under 45 psi of H2. The mixture was filtered through a plug of Celite, washed well with methanol and concentrated in vacuo to yield the amine as an oil in 84% yield.

후처리

  1. filtrationThe mixture was filtered through a plug of Celite
  2. washwashed well with methanol
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-90ad462de7e348f39f6a4c19431db71f
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674813B2

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