2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → 4-Fluoro-3-(4-trifluoromethylphenoxy)benzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate

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반응 단계

By the above procedure or the procedure of Example 3 α-cyano-2-fluoro-5-phenoxybenzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, 3-(4-fluorophenoxy)-4-fluorobenzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, α-cyano-3-(4-fluorophenoxy)-4-fluorobenzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, 4-fluoro-3-(4-methylphenoxy) benzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, 2-fluoro-5-(4-fluorophenoxy) benzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, and 4-fluoro-3-(4-trifluoromethylphenoxy)benzyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate is prepared by the reaction of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid or the acid chloride thereof with each of α-cyano-2-fluoro-5-phenoxybenzyl alcohol, 3-(4-fluorophenoxy)-4-fluorobenzyl alcohol, α-cyano-3-(4-fluorophenoxy)-4-fluorobenzyl alcohol,4-fluoro-3-(4-methylphenoxy) benzyl alcohol, 2-fluoro-5-(4-fluorophenoxy) benzyl alcohol, and 4-fluoro-3-(4-trifluoromethylphenoxy) benzyl alcohol, respectively.

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