Morpholine → HCID 11493308, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](SCC)=[CH:6][C:5]2=[O:15].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[CH:6][C:5]2=[O:15]

참가 물질

반응물 2

HCID 8083Morpholine

HCID 115872976-Bromo-2-ethylsulfanyl-chromen-4-one

생성물 1

HCID 11493308HCID 11493308, 화합물

실험 절차

Prepared from 6-Bromo-2-ethylsulfanyl-chromen-4-one (0.375 g, 1.35 mmol) and morpholine (0.54 ml, 6.25 mmol), affording a pale yellow solid. (0.0354 g, 1.14 mmol, 84%); m.p. 147-149° C.; ES+(m/e)=310.24 (M++1); (200 MHz, CDCl3) δ3.44 (4H, m); 3.77 (4H, m); 5.42 (1H, s); 7.11 (1H, d); 7.57 (1H, dd); 8.20 (1H, d)

후처리

customaffording a pale yellow solid

출처 및 근거

ORD 기록: ord-e9c4dd3a6efe44e8bb2d800e4d20e704
출처 데이터셋: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07674823B2

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