Iodine → 4-Iodo-2-(trifluoroacetyl)pyrrole

HRID 2243260노트

반응식

HRID 2243260 반응식
[F:1][C:2]([F:11])([F:10])[C:3]([C:5]1[NH:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[N+]([O-])([O-])=O.[NH4+].[Ce].[Ce].[I:19]I>C(#N)C>[I:19][C:8]1[CH:9]=[C:5]([C:3](=[O:4])[C:2]([F:1])([F:10])[F:11])[NH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 807IodineHCID 137637Ethanone, 2,2,2-trifluoro-1-(1H-pyrrol-2-yl)-HCID 86617141Dicerium ammonium nitrate

생성물 1

HCID 592104064-Iodo-2-(trifluoroacetyl)pyrrole수율 112.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

An acetonitrile solution (20 ml) of 2-(trifluoroacetyl)-1H-pyrrole (0.5 g), dicerium ammonium nitrate (0.84 g) and iodine (0.47 g) was refluxed for 2 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-2-(trifluoroacetyl)-1H-pyrrole (0.6 g).

후처리

  1. temperatureAfter cooling
  2. washthe reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride
  3. dry with materialAfter drying the organic layer with magnesium sulfate
  4. distillationthe solvent was distilled off under the reduced pressure

출처 및 근거

ORD 기록
ord-5a43c9b40c4a49bdb194188d71139fae
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674807B2

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