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Triethylamine → (2-Amino-4,5-difluorophenyl)amide

HRID 2243344
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HRID 2243344 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10].C(N(CC)CC)C.C1C=[CH:20][C:21](=[O:34])[C:22]2C=1C(C(Cl)=O)=C1C=2C=CC=C1>ClCCl>[CH:21]([O:34][CH:7]([CH3:6])[CH3:2])([CH3:22])[CH3:20].[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[NH-:10]
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참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 27367551,2-Diamino-4,5-difluorobenzeneHCID 87540947Fluoren-4-one-9-carboxylic acid chloride

생성물 2

HCID 7914Diisopropyl EtherHCID 131727951(2-Amino-4,5-difluorophenyl)amide수율 282%

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

실험 절차

The procedure used in stage 1 of Example 1 is followed, but starting from 1 g of 1,2-diamino-4,5-difluorobenzene, 1.9 ml of triethylamine and 1.7 g of fluoren-4-one-9-carboxylic acid chloride in 50 ml of dichloromethane. After stirring for 20 hours at room temperature, the precipitate that formed is filtered off, and washed with dichloromethane, with water, then with a 10% saturated aqueous solution of sodium hydrogen carbonate and, finally, with water. After formation of a paste with diisopropyl ether, in this way we obtain 1.4 g of (2-amino-4,5-difluorophenyl)amide of 9-oxo-9H-fluorene-4-carboxylic acid, in the form of a yellow powder, which is used as it is in the following stage, with the following characteristics:

후처리

  1. customthe precipitate that formed
  2. filtrationis filtered off
  3. washwashed with dichloromethane, with water

출처 및 근거

ORD 기록
ord-6fd5fc1458594209aa813a02f885044f
출처 데이터셋
uspto-grants-2010_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07674795B2

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