HCID 68527883, 화합물 → HCID 68527407, 화합물

HRID 2243391노트

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HRID 2243391 반응식
O[C:2]1([C:7]2[CH:8]=[C:9]([CH:32]=[CH:33][CH:34]=2)[O:10][C:11]2[C:16]([NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)=[O:19])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:6][CH:5]=[CH:4][CH2:3]1.OC(C1C=C(C=CC=1)OC1C(NC(NC2C=CC(OC(F)(F)F)=CC=2)=O)=CC=CN=1)(CC=C)CC=C>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.ClCCl>[CH:2]1([C:7]2[CH:8]=[C:9]([CH:32]=[CH:33][CH:34]=2)[O:10][C:11]2[C:16]([NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)=[O:19])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 2

HCID 68527883HCID 68527883, 화합물HCID 685297861-(2-(3-(4-Hydroxyhepta-1,6-dien-4-yl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea

생성물 1

HCID 68527407HCID 68527407, 화합물

시약·촉매·용매 2

HCID 11147261(1,3-Dimesitylimidazolidin-2-ylidene)(tricyclohexylphosphine)benzylidene ruthenium dichloride촉매2회HCID 6344Dichloromethane용매

실험 절차

1-(2-(3-(1-hydroxycyclopent-3-enyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea: A mixture of Example 640 (125 mg, 0.25 mmol) and Grubb's second generation catalyst (0.6 mg) in dichloromethane (70 mL) was stirred at rt for 16 h. An additional 1.0 mg of Grubb's second generation catalyst was added and the mixture was stirred at rt for an additional 17 h. Evaporation under reduced pressure afforded a residue which was filtered and purified using reverse-phase preparative HPLC. (M+H)+=472.

후처리

  1. customEvaporation under reduced pressure
  2. customafforded a residue which
  3. filtrationwas filtered
  4. custompurified

출처 및 근거

ORD 기록
ord-1927be4804df4927acdfc5dff492cc32
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07674828B2

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