Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Oxazepam | HCID 4616 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13125987 | — |
반응 단계
First, 1.2 of KF and then 2.9 g. of 3-hydroxy-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one are added to a mixture of 35 g. of HF and 15 ml. of pyridine and the mixture is stirred for 1 hour more. Working up in the customary manner using sodium carbonate solution/ethyl acetate gives 3-fluoro-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one, m.p. 235° (decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04232016 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-0b8984d3f2754273a3fcbf624a42a9e7 |
| 출처 메모 | uspto-grants-1980_11 |