Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hypofluorous acid, trifluoromethyl ester → 3-fluoro-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hypofluorous acid, trifluoromethyl ester | HCID 78989 | — |
| 반응물 | Dirazepic acid | HCID 23332610 | — |
| 반응물 | 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid | HCID 23332687 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3-fluoro-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13125993 | — |
반응 단계
3.7 g. of 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid, obtainable from 5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid and CF3OF, in 50 ml. of pyridine are boiled for 1 hour with 0.5 g. of CuO. The mixture is cooled, poured onto ice and filtered to give 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one, m.p. 211° (decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04232016 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-3354ae5334104c5188fa9d11bfab739d |
| 출처 메모 | uspto-grants-1980_11 |