Cyanuric chloride → tert-butyl (2R)-2-cyanopyrrolidine-1-carboxylate
반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13](=O)[NH2:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]#[N:14])=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
The title product of Example 10 (10.81 g, 50.45 mmol) and cyanuric chloride (5.58 g, 30.3 mmol) was stirred in DMF (30 mL) for 1 h. The reaction mixture was partitioned between ethyl acetate and water. The organic extracts were washed with aq. sodium carbonate, water, brine dried over sodium sulphate, filtered and concentrated to afford the title product (8.34 g, 84%) as a colourless oil.
후처리
- customThe reaction mixture was partitioned between ethyl acetate and water
- washThe organic extracts were washed with aq. sodium carbonate, water, brine
- dry with materialdried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-bc86d84ef4504911a8a7d9963b65b34e
- 출처 데이터셋
- uspto-grants-2010_03
- 특허 번호
- US07678796B2
반응 노트
불러오는 중…