Ethanol → Ethyl Pyridazine-4-carboxylate

HRID 2243886

반응식

HRID 2243886 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[CH:3][N:2]=1.OS(O)(=O)=O.[CH2:15](O)[CH3:16]>>[CH2:15]([O:8][C:7]([C:4]1[CH:5]=[CH:6][N:1]=[N:2][CH:3]=1)=[O:9])[CH3:16]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2761046Pyridazine-4-carboxylic Acid

생성물 1

HCID 10855652Ethyl Pyridazine-4-carboxylate수율 79%

실험 절차

To pyridazine-4-carboxylic acid (1.0 g, 8.1 mmol) in ethanol (10 mL) was added concentrated H2SO4 (4.2 mL) and then heated at reflux for 5 hours. The reaction mixture was cooled, concentrated in vacuo and basified with saturated Na2CO3. After filtration, the aqueous was extracted with ethyl acetate, dried over anhydrous Na2SO4, filtered and concentrated to give the title product as a dark yellow oil (970 mg, 79%).

후처리

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. concentrationconcentrated in vacuo
  5. filtrationAfter filtration
  6. extractionthe aqueous was extracted with ethyl acetate
  7. dry with materialdried over anhydrous Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b84e4f7eedb348819d43d40a83292036
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678796B2

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