Thionyl Chloride → 4-Chloro-7-fluoroquinazoline

HRID 2244084노트

반응식

HRID 2244084 반응식
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:15])=O>>[Cl:15][C:6]1[C:5]2[C:10](=[CH:11][C:2]([F:1])=[CH:3][CH:4]=2)[N:9]=[CH:8][N:7]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 1353984967-Fluoroquinazolin-4(3H)-one

생성물 1

HCID 162270134-Chloro-7-fluoroquinazoline

실험 절차

7-Fluoro-3H-quinazolin-4-one (8.2 g, 50 mmol) is heated at reflux in thionyl chloride (80 mL). Concentration affords the expected 4-Chloro-7-fluoro-quinazoline (9.1 g, ˜quant).

후처리

  1. concentrationConcentration

출처 및 근거

ORD 기록
ord-fadf7e4e1bc84828bb24083218bb893b
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678803B2

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