N,N-Dimethylaniline → HCID 9799174, 화합물

HRID 2244215노트

반응식

HRID 2244215 반응식
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[NH:7][CH2:6][C:5]=12.CN(C)C1C=CC=CC=1.[C:24]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:29]=[CH:28][C:27]([C:30](Cl)=[O:31])=[CH:26][CH:25]=1.O>O1CCOCC1>[C:24]1([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:25]=[CH:26][C:27]([C:30]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][N:4]3[CH:3]=[CH:2][CH:1]=[C:5]3[CH2:6]2)=[O:31])=[CH:28][CH:29]=1

참가 물질

6

반응물 4

HCID 949N,N-DimethylanilineHCID 962WaterHCID 841514-Phenylbenzoyl chlorideHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

생성물 1

HCID 9799174HCID 9799174, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 5.53 g (0.03 mol) of 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine in 50 mL of 1,4-dioxane was added 3.64 g (0.03 mol) of N,N-dimethylaniline followed by 6.50 g. of 4-biphenylcarbonyl chloride. The reaction solution was allowed to stand at room temperature for 2 hours and then slowly poured into 2 L of water. On cooling the mixture a crystalline white solid was formed which was collected and dried to provide the title compound (9.5 g). The product was used directly in the next step.

후처리

  1. temperatureOn cooling the mixture a crystalline white solid
  2. customwas formed which
  3. customwas collected
  4. customdried

출처 및 근거

ORD 기록
ord-9628790b887541ddb1efed3c326248f0
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678787B2

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