Acetone → 2'-Methanesulfonyl-biphenyl-4-carboxylic acid

HRID 2244220노트

반응식

HRID 2244220 반응식
CS[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1.[CH3:18]C(C)=O.O[O:23][S:24]([O-:26])=O.[K+]>O>[CH3:18][S:24]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=1)(=[O:26])=[O:23]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 225963254-(2-Methylthiophenyl)benzoic acidHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 225963472'-Methanesulfonyl-biphenyl-4-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 0.977 g (0.004 mole) of 2′-(methylthio)-1,1′-biphenyl-4-carboxylic acid of Example 14, Step A, in 25 mL of water and 75 mL of acetone was added 10 g. (0.163 mole) of oxone. The mixture was stirred overnight at room temperature. The acetone was removed in vacuo, and the residue was collected (0.80 g) and washed with water to provide a solid, m.p. 273-275° C.

후처리

  1. customThe acetone was removed in vacuo
  2. customthe residue was collected (0.80 g)
  3. washwashed with water
  4. customto provide a solid, m.p. 273-275° C.

출처 및 근거

ORD 기록
ord-25c7964819074c458752cce0579da0af
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678787B2

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