Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (S)-(-)-2-((3-Bromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Bromo-2,6-dimethoxybenzoic acid | HCID 2774744 | — |
| 반응물 | (+)-2-(Aminomethyl)-1-ethylpyrrolidine d-tartrate | HCID 70527605 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (S)-(-)-2-((3-Bromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride | HCID 15565708 | — |
반응 단계
Using the same method as for compound in Example 14, except of the addition of triethylamine, this compound was prepared from 8.4 g (0.032 mol) of 3-bromo-2,6-dimethoxybenzoic acid, 20 ml of thionyl chloride and 9.0 g (0.032 mol) of (+)-2-(aminomethyl)-1-ethylpyrrolidine d-tartrate. Yield: 7.5 g, m.p. 166°-68° C., [α]D20° =10.7° (0.5% in water).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04232037 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-678e8210f1d94d6c960d9c3da0f045ea |
| 출처 메모 | uspto-grants-1980_11 |