Water → 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid

HRID 2244324노트

반응식

HRID 2244324 반응식
[F:1][C:2]([F:15])([C:7]1[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=1)[C:3]([F:6])([F:5])[F:4].[OH-:16].[K+].[OH2:18]>C(O)C>[F:1][C:2]([F:15])([C:7]1[CH:14]=[CH:13][C:10]([C:11]([OH:18])=[O:16])=[CH:9][CH:8]=1)[C:3]([F:6])([F:5])[F:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 147741854-(Pentafluoroethyl)benzonitrile

생성물 1

HCID 230678834-(1,1,2,2,2-Pentafluoroethyl)benzoic acid수율 85%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-pentafluoroethyl-benzonitrile (2.98 g, 13.5 mmol) and potassium hydroxide (3.03 g, 54.0 mmol) in water (40 mL) and ethanol (20 mL) was heated at reflux for 16 h. After cooling, the solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) produced the title compound (2.76 g, 85%). White solid, MS (ISP) 238.9 (M−H)−.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. temperatureAfter cooling
  4. customthe solution was partitioned between 1 M aq. hydrochloric acid solution and ethyl acetate
  5. washThe organic layer was washed with brine
  6. dry with materialdried (MgSO4)
  7. customevaporated

출처 및 근거

ORD 기록
ord-ba0ebee87df542b5a70dc5d9a658819f
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678818B2

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