HCID 58674939, 화합물 → HCID 58674940, 화합물

HRID 2244419노트

반응식

HRID 2244419 반응식
[CH3:1][C:2]1[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=[C:4]([N+:12]([O-])=O)[N:3]=1>C(O)C.[Pd]>[NH2:12][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 58674939HCID 58674939, 화합물

생성물 1

HCID 58674940HCID 58674940, 화합물수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Acetic acid 2-methyl-6-nitro-pyridin-3-yl ester (0.30 g, 1.53 mmol) was dissolved in ethanol. 10% Pd/C (0.04 g, 0.38 mmol) was added, and the mixture was put under an atmosphere of hydrogen and stirred vigorously for 50 min at room temperature. The catalyst was filtered off, washing with ethanol, and the solvent removed under vacuum to yield acetic acid 6-amino-2-methyl-pyridin-3-yl ester (0.24 g, 95%) as a white solid, MS (ISP): m/e=166.2 (M+), which was used crude.

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashing with ethanol
  3. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-197da1023afe4f79ba48c26dc27c8dcd
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678815B2

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