Tetrahydrofuran → HCID 44156297, 화합물

HRID 2244463노트

반응식

HRID 2244463 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH:14]=[C:13]([Si](C)(C)C)[N:12]=[N:11]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1COCC1>C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH:14]=[CH:13][N:12]=[N:11]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 8028TetrahydrofuranHCID 684073741-(3-Nitro-phenyl)-4-trimethylsilanyl-1H-[1,2,3]triazole

생성물 1

HCID 44156297HCID 44156297, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

1-(3-Nitro-phenyl)-4-trimethylsilanyl-1H-[1,2,3]triazole (16.7 g, 64 mmol) tetrabutylammonium fluoride in THF (1M, 100 ml, 100 mmol) were stirred at room temperature for 24 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was dried with magnesium sulfate, filtered and evaporated. The crude product was purified by chromatography on silica gel (hexane/ethyl acetate 1:1) and the desired product was obtained as a brown solid (9.96 g, 82%), mp 80-83° C.

후처리

  1. washwashed with water and brine
  2. dry with materialThe organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customevaporated
  5. customThe crude product was purified by chromatography on silica gel (hexane/ethyl acetate 1:1)

출처 및 근거

ORD 기록
ord-caf0695b9ce4428eada68a063e578432
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678815B2

반응 노트

불러오는 중…