Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → Norquetiapine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 2-((2-Aminophenyl)thio)benzoic acid | HCID 10955828 | — |
| 생성물 | Norquetiapine | HCID 11369918 | — |
반응 단계
Next, 2-(2-aminophenylthio)benzoic acid which is expressed by the above Formula 7 is simultaneously subjected to cyclization and chlorination reactions in the presence of a equivalent amount of halogenating agent and base in an organic solvent, and then reacted with piperazine without separation, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine expressed by the above Formula 4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07678902B2 |
| 출처 데이터셋 | uspto-grants-2010_03 |
| ORD ID | ord-530637aa1d654a4abfb42233554eb700 |
| 출처 메모 | uspto-grants-2010_03 |