Thionyl Chloride → 1-Chloro-6-(trifluoromethyl)indane

반응식

[F:1][C:2]([F:14])([F:13])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2O)=[CH:5][CH:4]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:14])([F:13])[F:1])[CH:11]=2)[CH2:7][CH2:8]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 592126636-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-OL

생성물 1

HCID 592126531-Chloro-6-(trifluoromethyl)indane수율 90%

실험 절차

6-(Trifluoromethyl)indan-1-ol (1.52 g, 7.5 mmol) was dissolved in thionyl chloride (15 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated in vacuo to provide the title compound (1.5 g, 90%).

후처리

concentrationthe solution was concentrated in vacuo

출처 및 근거

ORD 기록: ord-b1402b625a0442f7b9edec8da65630b2
출처 데이터셋: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07678798B2

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