Triethylamine → (S)-N-methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

HRID 22449

반응식

HRID 22449 반응식
C([N:3]([CH2:6]C)CC)C.[C:8]([NH:15][C@H:16]([C:21]([OH:23])=O)[CH2:17][CH:18]([CH3:20])[CH3:19])([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[C:24](C1NC=CN=1)(C1NC=CN=1)=[O:25]>ClCCl>[CH3:24][O:25][N:3]([CH3:6])[C:21](=[O:23])[C@H:16]([CH2:17][CH:18]([CH3:19])[CH3:20])[NH:15][C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9]

참가 물질

5

반응물 3

HCID 8471Triethylamine2회HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 5250894Bis-(1H-imidazol-2-YL)-methanone

생성물 1

HCID 11119284(S)-N-methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Triethylamine (10 ml) is added to a stirred solution of Boc-Leucine in dichloromethane. Then sequentially, carbonyl-diimidazole (10 mmol) are added followed by, N-dimethylhydroxyamine hydrochloride (11 mmol), and triethylamine (11 mmol). The reaction is monitored by TLC, was found to be completely within an hour. The mixture is diluted with dicloromethane (250 ml) and washed successively with 1N HCl, and a saturated sodium chloride solution. The organic solution was dried with magnesium sulfate, and the solvent evaporated to give the desired product (9.0 mmol yield).

후처리

  1. waitto be completely within an hour
  2. washwashed successively with 1N HCl
  3. dry with materialThe organic solution was dried with magnesium sulfate
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-56486a97160b42fb8d452a058dc72998
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428019

연결된 노트

불러오는 중…