Dextroamphetamine → 4-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

HRID 224565

반응식

HRID 224565 반응식
[CH3:1][C@H:2]([NH2:10])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.C(N(CC)CC)C.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>C1C=CC=CC=1>[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24]([NH:10][CH:2]([CH3:1])[CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 5826DextroamphetamineHCID 73974-Toluenesulfonyl chlorideHCID 8471Triethylamine

생성물 1

HCID 132498614-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

Dextro amphetamine (200 g) and triethylamine (164 g) were dissolved in 1500 ml. of benzene. A solution of p-toluene sulfonyl chloride (310g) in 500 ml. of benzene was added dropwise to the cooled solution during one hour. The reaction mixture was stirred for three hours at room temperature, then allowed to stand for approximately 16 hours (over night) at room temperature (approximately 20° C.). The salts were filtered off and the benzene solution was washed with dilute HCl, water and brine. Evaporation of the solvent afforded an oil.

후처리

  1. waitto stand for approximately 16 hours
  2. customat room temperature
  3. custom(approximately 20° C.)
  4. filtrationThe salts were filtered off
  5. washthe benzene solution was washed with dilute HCl, water and brine
  6. customEvaporation of the solvent
  7. customafforded an oil

출처 및 근거

ORD 기록
ord-b403412b2678470f8919b8be94d0df2d
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233217

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