Glyoxal, phenyl-, hydrate → HCID 24830621, 화합물

HRID 2245925노트

반응식

HRID 2245925 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3[N:13]([NH2:18])[C:14]([NH2:17])=[N:15][N:16]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.O.O=[C:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:22]=O>C(O)(=O)C.CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]3[N:13]4[N:18]=[CH:22][C:21]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)=[N:17][C:14]4=[N:15][N:16]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 12215922Glyoxal, phenyl-, hydrateHCID 59216295HCID 59216295, 화합물

생성물 1

HCID 24830621HCID 24830621, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 887Methanol용매

실험 절차

A mixture of 5-[1-(4-methoxyphenyl)cyclopropyl]-4H-1,2,4-triazole-3,4-diamine (70.2 mg, 0.286 mmol) and oxo(phenyl)acetaldehyde hydrate (0.0435 g, 0.286 mmol) in acetic acid (1.2 mL) was stirred at RT overnight. The mixture was diluted with methanol (3.0 mL) and subject to preparative RP-HPLC to afford the two regioisomers.

후처리

  1. customto afford the two regioisomers

출처 및 근거

ORD 기록
ord-62e2ea15f87547dd814f5b0421dd51c0
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07683060B2

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