4-(3-(Trifluoromethyl)phenyl)-1-piperazineethanol → Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

HRID 224594노트

반응식

HRID 224594 반응식
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17].F[C:28](F)(F)C1C=C(N2CCN(CCO)CC2)C=CC=1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH2:19][CH3:28])=[O:17]

참가 물질

3

반응물 2

HCID 2179944-(3-(Trifluoromethyl)phenyl)-1-piperazineethanolHCID 23331699Methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate

생성물 1

HCID 86737324Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

실험 절차

Using the procedure of Example 13, methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate and 2-[-4-(3-trifluoromethylphenyl)-piperazin-1-yl]-ethanol were reacted to obtain 2-[4-3-trifluoromethylphenyl)-piperazin-1-yl]-ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate. The said product was dissolved in absolute ethanol and an ethanolic solution of hydrogen chloride was added thereto followed by anhydrous ether. The mixture crystallized was vacuum filtered and the product was washed with anhydrous ether and was dried to form the desired hydrochloride salt melting at 230°-240° C.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-6cb0733c43ea4c23ba30073be53b3ff7
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233305

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