홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Iodide → 1'-(2-Phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

HRID 224612
노트
인쇄 미리보기

반응식

HRID 224612 반응식
[O:1]([CH2:8][CH2:9][Cl:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][N:12]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[C:13]1=[O:26].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>O.CN(C)C=O>[ClH:10].[O:1]([CH2:8][CH2:9][N:17]1[CH2:18][CH2:19][C:14]2([C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:12]([CH3:11])[C:13]2=[O:26])[CH2:15][CH2:16]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 12156Benzene, (2-chloroethoxy)-HCID 215841551-Methylspiro[indoline-3,4'-piperidin]-2-one

생성물 1

HCID 705944601'-(2-Phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

시약·촉매·용매 2

HCID 962
Water
용매
HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1.63 g of phenoxyethylchloride, 1.5 g of 1-methyl-2-oxo-indoline-3-spiro-4'-piperidine, 1.44 g of anhydrous potassium carbonate, 0.1 g of potassium iodide and 30 ml of dimethylformamide was stirred at 90°-100° C. for 5 hours. The resulting mixture was poured into water and was extracted with diethylether. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo. Thus obtained oil was treated with hydrochloric acid to give 1'-(2-phenoxyethyl)-1-methyl-2-oxo-indoline-3-spiro-4'-piperidine hydrochloride

후처리

  1. extractionwas extracted with diethylether
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo
  5. additionThus obtained oil was treated with hydrochloric acid

출처 및 근거

ORD 기록
ord-c453dcfec0cf41048b5306cdb9a7f3c2
출처 데이터셋
uspto-grants-1980_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04233307

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트