2-Chloro-3-methoxypyridine → 2,3-Dimethoxypyridine

HRID 2246188

반응식

HRID 2246188 반응식
Cl[C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:10][O-:11].[Na+]>CN(C)C=O>[CH3:10][O:11][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 1042522-Chloro-3-methoxypyridineHCID 10942334Sodium Methoxide

생성물 1

HCID 46578092,3-Dimethoxypyridine수율 29%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3-equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 100° C. until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74° C.; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29% yield for two steps).

후처리

  1. customThe reaction mixture was then quenched with water
  2. extractionextracted with dichloromethane
  3. washThe combined extracts were washed with water
  4. concentrationconcentrated
  5. distillationdistilled (74° C.; 5 mm Hg)

출처 및 근거

ORD 기록
ord-7fa384e2807d4d1789c437b8efa79210
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687487B2

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