Hydroxylamine → 2-Fluoro-N'-hydroxy-4-(methanesulfonyl)benzene-1-carboximidamide
반응식
[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:14][OH:15]>C(O)C>[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4](=[N:14][OH:15])[NH2:5]참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
To a stirred solution of the product from Step E (0.29 g, 0.144 mmol) in ethanol (15 mL) was added hydroxylamine (50% in water, 3.0 mL). The reaction was heated at 90° C. for 3 h. The reaction was then concentrated to give the desired product.
후처리
- concentrationThe reaction was then concentrated
출처 및 근거
- ORD 기록
- ord-c72f38cdac23496b9ee55ba9e6cbc827
- 출처 데이터셋
- uspto-grants-2010_03
- 특허 번호
- US07687492B2
반응 노트
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