[1,3]Thiazolo[5,4-b]pyridin-2-amine → HCID 11666499, 화합물

반응식

C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2Cl)(=O)C.[N:16]1[C:24]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[S:18][C:17]=1[NH2:25]>>[OH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2[NH:25][C:17]1[S:18][C:19]2[C:24]([N:16]=1)=[CH:23][CH:22]=[CH:21][N:20]=2

참가 물질

반응물 2

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amine2회

HCID 189676244-Chloroquinazolin-6-yl acetate

생성물 1

HCID 11666499HCID 11666499, 화합물

실험 절차

The compound of Example 38 was manufactured using 6-acetoxy-4-chloro-quinazoline and thiazolo[5,4-b]pyridin-2-yl-amine by the same method as in Example 1 for the manufacture of 6-iodoquinazolin-4-yl)-thiazolo[5,4-b]pyridin-2-yl-amine, by a similar method thereto or by a combination of such a method with a conventional method.

출처 및 근거

ORD 기록: ord-259ff7175f574d4497dc71c4c0b4b6ad
출처 데이터셋: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07687502B2

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