Benzene → n-Heptyl-diethyl-thiourea

HRID 224630

반응식

HRID 224630 반응식
[CH2:1]([N:8]=[C:9]=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:11]([NH:13]CC)[CH3:12].[CH:16]1C=CC=C[CH:17]=1>>[CH2:1]([N:8]([CH2:16][CH3:17])[C:9]([NH:13][CH2:11][CH3:12])=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 3

HCID 241BenzeneHCID 8021DiethylamineHCID 78152Heptane, 1-isothiocyanato-

생성물 1

HCID 20555250n-Heptyl-diethyl-thiourea

실험 절차

To a solution of 3.14 grams (0.02 mole) of heptyl isothiocyanate dissolved in 15 milliliters of benzene was added 1.46 grams (0.02 mole) of diethylamine. The temperature rose to about 50° C. The mixture was refluxed on a steam bath for 20 minutes until a neutral pH was obtained. The mixture was then evaporated under vacuum to give 4.8 grams of n-heptyl-diethyl-thiourea. To this product, 4.1 grams (0.02 mole) of bromoethylamine hydrobromide and 25 milliliters of ethanol 2B was added. The mixture was refluxed on a steam bath for four hours and then permitted to stand overnight at ambient temperature. The mixture was then refluxed an additional three hours. The mixture was evaporated under vacuum to yield 8.83 grams of a yellow gel-like liquid, ND30 =1.5410. The structure of the product was confirmed by NMR.

후처리

  1. customrose to about 50° C
  2. temperatureThe mixture was refluxed on a steam bath for 20 minutes until a neutral pH
  3. customwas obtained
  4. customThe mixture was then evaporated under vacuum

출처 및 근거

ORD 기록
ord-6eeeb19703db41dd8f6ffd9972ba5eb5
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233318

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