4-Nitroaniline → 2-(2-chloroethoxy)-N-(4-nitrophenyl)acetamide

HRID 2246805노트

반응식

HRID 2246805 반응식
Cl[C:2]1([Cl:8])[CH2:7][O:6][CH2:5][CH2:4][O:3]1.[N+:9]([C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1)([O-:11])=[O:10]>>[Cl:8][CH2:2][CH2:7][O:6][CH2:5][C:4]([NH:16][C:15]1[CH:17]=[CH:18][C:12]([N+:9]([O-:11])=[O:10])=[CH:13][CH:14]=1)=[O:3]

참가 물질

3

반응물 2

HCID 74754-NitroanilineHCID 124243252,2-Dichloro-1,4-dioxane

생성물 1

HCID 116158572-(2-chloroethoxy)-N-(4-nitrophenyl)acetamide

반응 조건

온도
80 °C

실험 절차

1.53 g of a mixture of 2-chlorodioxene and 2,2-dichlorodioxane (molar ratio 1:1) are added to 1.00 g (7.24 mmol) of 4-nitroaniline, and the mixture is heated to 80° C. with stirring. A solid brown mass forms within one hour and becomes liquid again and crystallises within the following 12 hours. The crude product is recrystallised from ethanol with addition of water, giving 1.80 g of 2-(2-chloroethoxy)-N-(4-nitrophenyl)acetamide (“A1”) as yellowish crystals, m.p. 101-102° C. 1H-NMR (d6-DMSO): δ=3.82 (m; 4H), 4.23 (s; 2H), 7.91 (d, J=9 Hz, 2H), 8.23 (d, J=9 Hz, 2H), 10.34 (s, 1H).

후처리

  1. customcrystallises within the following 12 hours
  2. customThe crude product is recrystallised from ethanol with addition of water

출처 및 근거

ORD 기록
ord-f977f05c02f14736b1bdb0c0309a60a6
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687624B2

반응 노트

불러오는 중…