Potassium Carbonate → 4-(4-Nitrophenyl)-morpholin-3-ON

HRID 2246806노트

반응식

HRID 2246806 반응식
Cl[CH2:2][CH2:3][O:4][CH2:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:7].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N+:15]([C:12]1[CH:13]=[CH:14][C:9]([N:8]2[CH2:2][CH2:3][O:4][CH2:5][C:6]2=[O:7])=[CH:10][CH:11]=1)([O-:17])=[O:16]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 116158572-(2-chloroethoxy)-N-(4-nitrophenyl)acetamide

생성물 1

HCID 114473754-(4-Nitrophenyl)-morpholin-3-ON

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1.3 1 kg of “A1” is dissolved in 5 liters of acetonitrile at room temperature, 835 g of potassium carbonate are added, and the mixture is stirred at this temperature for 18 hours. The mixture is warmed to 50° and worked up analogously to Example 6, giving 4-(4-nitrophenyl)-3-oxomorpholine (“A2”), m.p. 150-152°.

후처리

  1. temperatureThe mixture is warmed to 50°

출처 및 근거

ORD 기록
ord-b7623c50dd47441493dfdfc3dc886d17
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687624B2

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