4-Aminobenzonitrile → 4-(3-Oxo-4-morpholinyl)benzonitrile

반응식

[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.Cl[C:11]1(Cl)[CH2:16][O:15][CH2:14][CH2:13][O:12]1>>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([N:1]2[CH2:14][CH2:13][O:12][CH2:11][C:16]2=[O:15])=[CH:3][CH:4]=1)#[N:7]

참가 물질

반응물 2

HCID 133964-Aminobenzonitrile

HCID 124243252,2-Dichloro-1,4-dioxane

생성물 1

HCID 684509884-(3-Oxo-4-morpholinyl)benzonitrile

반응 조건

온도: 80 °C

실험 절차

A mixture of 959 mg (8.12 mmol) of 4-aminobenzonitrile and 1.12 g of a mixture of 2-chlorodioxene and 2,2-dichlorodioxane (molar ratio 89:11) is heated at 80° C. with stirring for 18 hours. On cooling to room temperature, the product crystallises: 1.9 g of 2-(2-chloroethoxy)-N-(4-cyanophenyl)acetamide as yellowish crystals. 1H-NMR (d 6-DMSO): δ=3.82 (m; 4H), 4.19 (s; 2H), 7.78 (d, J=8 Hz, 2H), 7.85 (d, J=8 Hz, 2H), 10.22 (s, 1H).

후처리

temperatureOn cooling to room temperature
customthe product crystallises

출처 및 근거

ORD 기록: ord-9b00de00eb4341d0ae3d7d4aed852ca2
출처 데이터셋: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07687624B2

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