Ethyl valerate → Octa-1,2-dien-4-one

HRID 224698

반응식

HRID 224698 반응식
[CH2:1]([Mg]Br)[C:2]#[CH:3].[C:6](OCC)(=[O:11])[CH2:7][CH2:8][CH2:9][CH3:10]>CCOCC>[CH2:3]=[C:2]=[CH:1][C:6](=[O:11])[CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

4

반응물 2

HCID 10882Ethyl valerateHCID 178455849HCID 178455849, 화합물

생성물 1

HCID 11194330Octa-1,2-dien-4-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

반응 조건

온도
-78 °C

실험 절차

To a stirred solution of 0.50 moles of propargylmagnesium bromide in 340 ml. of ether at -78° C. is added a solution of 65.2 g. (0.50 moles) of the ethyl valerate in 100 ml. of ether during 60 minutes. The solution is stirred at -78° C. for 30 minutes and then hydrolyzed by pouring onto a mixture of ice and ether. The ether layer is washed with brine, treated with hydroquinone, dried over magnesium sulfate, and concentrated.

후처리

  1. washThe ether layer is washed with brine
  2. additiontreated with hydroquinone
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6c329e36c1e741b9b076e225f0e0db3b
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04233453

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