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Water → 3-phenyl-1-[2-(phthalimido)ethyl]-1H-pyrazolo[4,3-c]pyridine

HRID 22470
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HRID 22470 반응식
[C:1]1([C:7]2[C:11]3[CH:12]=[N:13][CH:14]=[CH:15][C:10]=3[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrCC[C:19]1[CH:29]=[CH:28][CH:27]=[C:21]2[C:22]([NH:24][C:25](=O)[C:20]=12)=[O:23].[C:30]([O-:33])([O-])=O.[K+].[K+].O.[CH3:37]N(C)C=O>>[C:1]1([C:7]2[C:11]3[CH:12]=[N:13][CH:14]=[CH:15][C:10]=3[N:9]([CH2:37][CH2:25][N:24]3[C:22](=[O:23])[C:21]4=[CH:20][CH:19]=[CH:29][CH:28]=[C:27]4[C:30]3=[O:33])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium Carbonate3회HCID 138011253-Phenyl-1H-pyrazolo[4,3-c]pyridineHCID 219600212-Bromoethylphthalimide3회

생성물 1

HCID 199304793-phenyl-1-[2-(phthalimido)ethyl]-1H-pyrazolo[4,3-c]pyridine

반응 조건

온도
90 °C

실험 절차

3-Phenyl-1H-pyrazolo[4,3-c]pyridine (1.95 g) was suspended in 50 ml of dimethylformamide to which 2-bromoethylphthalimide (2.54) and K2CO3 (1.4 g) had been added. This mixture was stirred and warmed at 90° C. for 4 hours and then an additional 1.25 g of 2-bromoethylphthalimide and 0.7 g of K2CO3 were added. After 2 more hours another 0.60 g of 2-bromoethylphthalimide and 0.4 g of K2CO3 were added and stirring and heating were continued for an additional 90 minutes. At the end of this time, the reaction mixture was poured into H2O and the product filtered off and dried to give 2.63 of 3-phenyl-1-[2-(phthalimido)ethyl]-1H-pyrazolo[4,3-c]pyridine.

후처리

  1. additionhad been added
  2. stirringstirring
  3. temperatureheating
  4. filtrationthe product filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-ed59b1e807ba42099f1985e5f75dc60f
출처 데이터셋
uspto-grants-1995_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05428169

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