HCID 21961374, 화합물 → 1-Ethyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-amine

HRID 2247226노트

반응식

HRID 2247226 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=2)[C:6]([CH3:17])([CH3:16])[CH2:5][CH2:4]1)[CH3:2]>CCOC(C)=O.[Pd]>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH2:13])[CH:11]=2)[C:6]([CH3:16])([CH3:17])[CH2:5][CH2:4]1)[CH3:2]

참가 물질

4

반응물 1

HCID 21961374HCID 21961374, 화합물

생성물 1

HCID 219614881-Ethyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

The mixture of 1-ethyl-4,4-dimethyl-7-nitro-1,2,3,4-tetrahydro-quinoline (0.28 g) and Pd/C (0.060 g, 10% wt) in 10 ml of EtOAc was placed under H2 which was provided by a balloon and stirred at RT overnight. Then the mixture was filtered through Celite®, condensed, and the residue was purified by flash column chromatography (2% of EtOAc in CH2Cl2). The titled compound was obtained as a pink oil. MS(ES+): 204.8 (M+H)+. Calc'd for C11H16N—204.31.

후처리

  1. customwas provided by a balloon
  2. filtrationThen the mixture was filtered through Celite®, condensed
  3. customthe residue was purified by flash column chromatography (2% of EtOAc in CH2Cl2)

출처 및 근거

ORD 기록
ord-aad16a98d2994175b74dbc633b12b88d
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687643B2

반응 노트

불러오는 중…