HCID 54518938, 화합물 → Ethyl (2R)-2,3-dihydroxy-2-methylpropanoate
반응식
C([O:8][C@:9]([CH3:17])([CH2:15][OH:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[OH:8][C@:9]([CH3:17])([CH2:15][OH:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11]참가 물질
5
실험 절차
22 g of ethyl (R)-2-benzyloxy-3-hydroxy-2-methyl-propionate (manufactured in accordance with Example 1) in 150 ml of ethyl acetate were hydrogenated with hydrogen gas in the presence of 11 g of 5% by weight palladium/carbon catalyst up to the cessation of the hydrogen uptake. The catalyst was filtered off, washed with ethyl acetate (2×50 ml), the filtrate was concentrated in the vacuum and the residual oil was distilled at 56°-57°/0.1 mmHg. There were obtained 12.7 g of ethyl (R)-2,3-dihydroxy-2-methyl-propionate in the form of a colorless viscous liquid. [α]D =+0.339° (undiluted);=+11.6° (c=2.12 in chloroform).
후처리
- filtrationThe catalyst was filtered off
- washwashed with ethyl acetate (2×50 ml)
- concentrationthe filtrate was concentrated in the vacuum
- distillationthe residual oil was distilled at 56°-57°/0.1 mmHg
출처 및 근거
- ORD 기록
- ord-00253f1f3bf749db9dd323445dcc9b6b
- 출처 데이터셋
- uspto-grants-1980_11
- 특허 번호
- US04234490
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