Acetylthiourea → N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide

HRID 2247341노트

반응식

HRID 2247341 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[C:15]([NH:18][C:19]([NH2:21])=[S:20])(=[O:17])[CH3:16]>C(O)C>[CH3:4][C:3]1[N:21]=[C:19]([NH:18][C:15](=[O:17])[CH3:16])[S:20][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 2723593AcetylthioureaHCID 85861734HCID 85861734, 화합물

생성물 1

HCID 85861731N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide수율 52%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of 1-bromo-1-(3-nitro-phenyl)-propan-2-one (Example 49a) (0.5 g, 1.94 mmol) and N-acetylthiourea (0.23 g, 1.94 mmol) in ethanol (10 ml) is stirred at 70° C. for 2 hours. After cooling the reaction to room temperature, the precipitated product is removed by filtration and dried under vacuum to give the titled compound (0.28 g).

후처리

  1. temperatureAfter cooling
  2. customthe reaction to room temperature
  3. customthe precipitated product is removed by filtration
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-801c59bd37d740668fe5a698b1bef334
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687637B2

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