2-Bromobenzylamine hydrochloride → 2-Bromo-N-(tert-butoxycarbonyl)benzylamine

HRID 2247434노트

반응식

HRID 2247434 반응식
Cl.[Br:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH2:6].[C:11](OC([O-])=O)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>O1CCCC1>[Br:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH:6][C:11](=[O:12])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 27242022-Bromobenzylamine hydrochlorideHCID 22064466Tert-butyldicarbonate

생성물 1

HCID 70183002-Bromo-N-(tert-butoxycarbonyl)benzylamine수율 82.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

15.0 g of 2-Bromobenzylamine hydrochloride was dissolved in 100 ml of tetrahydrofuran, and a solution of 13 g of t-butyl dicarbonate in tetrahydrofuran (25 ml) was added thereto. The mixture was stirred at room temperature for 1 hour, and then the solvent was evaporated. The residue was dissolved in ethyl acetate, and washed successively with 1N hydrochloric acid and brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated, to give 16.0 g of the title compound.

후처리

  1. customthe solvent was evaporated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed successively with 1N hydrochloric acid and brine
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-b11eb93fd399418695ca779846d3ebfa
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07687664B2

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