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Methyl (3'-benzyloxy-4'-methoxybiphenyl-3-yl)acetate → Methyl (3'-hydroxy-4'-methoxybiphenyl-3-yl)acetate

HRID 2247438
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HRID 2247438 반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[CH:18]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.C(O)C.[C].[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[CH:18]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 59219255Methyl (3'-benzyloxy-4'-methoxybiphenyl-3-yl)acetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 59219199Methyl (3'-hydroxy-4'-methoxybiphenyl-3-yl)acetate수율 95.6%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매
HCID 8857
Ethyl Acetate
용매

실험 절차

1.35 g of Methyl (3′-benzyloxy-4′-methoxybiphenyl-3-yl)acetate was dissolved in a mixed solvent of 10 ml of ethyl acetate and 30 ml of ethanol, then 500 mg of 10% palladium-carbon was added thereto, and the mixture was stirred overnight in a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was concentrated. The residue was purified by silica gel column chromatography, to give 970 mg of the title compound in the 3:1 hexane-ethyl acetate fraction.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-9969b9a89e8b45bdb1b159b4e9df98f6
출처 데이터셋
uspto-grants-2010_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07687664B2

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