Methylthiouracil → 6-methyl-2-[(pyridin-2-yl)methyl]thio-4(3H)-pyrimidinone

HRID 2247853노트

반응식

HRID 2247853 반응식
[CH3:1][C:2]1[NH:7][C:6](=[S:8])[NH:5][C:4](=[O:9])[CH:3]=1.[Cl-].Cl[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][NH+:14]=1>>[CH3:1][C:2]1[N:7]=[C:6]([S:8][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[NH:5][C:4](=[O:9])[CH:3]=1

참가 물질

3

반응물 2

HCID 667493MethylthiouracilHCID 113441842-(Chloromethyl)pyridin-1-ium chloride

생성물 1

HCID 1355591866-methyl-2-[(pyridin-2-yl)methyl]thio-4(3H)-pyrimidinone수율 45%

실험 절차

The title compound is prepared from 6-methyl-2-thiouracil and 2-chloromethylpyridinium chloride by using the process described in Example 12. After recrystallization from 2-propanol the title compound is obtained as a yellowish crystalline substance in a yield of 45%, m.p.: 154°-156° C.

후처리

  1. customAfter recrystallization from 2-propanol the title compound
  2. customis obtained as a yellowish crystalline substance in a yield of 45%, m.p.: 154°-156° C.

출처 및 근거

ORD 기록
ord-28250a125de84638a063a1da87e71c1c
출처 데이터셋
uspto-grants-1991_08
특허 번호
US05037830

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