Peracetic Acid → Sulbactam

HRID 224788

반응식

HRID 224788 반응식
[CH3:1][C:2]1([CH3:13])S[C@@H:5]2[CH2:7][C:8](=[O:9])[N:4]2[C@H:3]1[C:10]([OH:12])=[O:11].C(OO)(=O)C.[S:19](=[O:22])(O)[O-:20].[Na+]>O.C(OCC)(=O)C>[CH3:1][C:2]1([CH3:13])[S:19](=[O:22])(=[O:20])[C@@H:5]2[CH2:7][C:8](=[O:9])[N:4]2[C@H:3]1[C:10]([OH:12])=[O:11]

참가 물질

6

반응물 3

HCID 6585Peracetic Acid2회HCID 6891Penicillanic AcidHCID 23665763Sodium Bisulfite

생성물 1

HCID 130313Sulbactam

시약·촉매·용매 2

HCID 962Water용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a stirred solution of 1.78 g. of penicillanic acid in water, at pH 7.5, was added 1.46 ml. of 40% peracetic acid, followed by an additional 2.94 ml. of 40% peracetic acid 30 minutes later. The reaction mixture was stirred for 3 days at room temperature and then it was diluted with ethyl acetate and water. Solid sodium bisulfite was added to decompose excess peracid, and then the pH was adjusted to 1.5. The ethyl acetate layer was removed, dried (Na2SO4) and evaporated in vacuo. The residue was a 3:2 mixture of penicillanic acid 1,1-dioxide and penicillanic acid 1-oxide.

후처리

  1. customThe ethyl acetate layer was removed
  2. dry with materialdried (Na2SO4)
  3. customevaporated in vacuo
  4. additiona 3:2 mixture of penicillanic acid 1,1-dioxide and penicillanic acid 1-oxide

출처 및 근거

ORD 기록
ord-27f7b24ee1314ec1a204acc25be7bc42
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234579

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