1-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine → 1-Acetyl-2[1-(4-fluorophenyl)-3-methyl-5-pyrazolyl] amino-2-imidazoline

HRID 224829노트

반응식

HRID 224829 반응식
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1.[C:15]([N:18]1[CH2:22][C:21](=O)[N:20]=[CH:19]1)(=[O:17])[CH3:16]>>[C:15]([N:18]1[CH2:22][CH2:21][N:20]=[C:19]1[NH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1)(=[O:17])[CH3:16]

참가 물질

3

반응물 2

HCID 23803541-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amineHCID 22350258N-acetyl-2-imidazolinone

생성물 1

HCID 127637961-Acetyl-2[1-(4-fluorophenyl)-3-methyl-5-pyrazolyl] amino-2-imidazoline

실험 절차

5-Amino-1-(4-fluorophenyl)-3-methylpyrazole (25 g.) and 1-acetyl-2-imidazolinone (20.2 g.) were reacted as described in Example I to give 21.97 g. product, mp 189°-191°

후처리

  1. customto give 21.97 g

출처 및 근거

ORD 기록
ord-883f20b6ffa14504ae8509c9891eec0c
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04234594

반응 노트

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